St Helens make the short trip to Widnes on Sunday with the aim of securing another win against their local rivals.
The Saints, who have already confirmed their place in the play-off semi-finals, will be looking to make it a hat-trick of victories over Denis Betts’ men in 2016.
Keiron Cunningham’s side defeated the Vikings on Easter Monday, before edging through 12-10 at Langtree Park in July.
The Saints’ league double over the Vikings this campaign only compounded their stellar record over the home side – Widnes’ only victory in the last six meetings between the two sides came in the Karalius Cup pre-season tie in January.
But while the hosts have struggled for wins against their local rivals in recent years, the Vikings will be galvanised after having only lost by two points in July.
The two clubs were locked at10-10 before Mark Percival stepped up with the boot to provide a crucial penalty kick to make it 12-10.
Denis Betts’ side come into round six off the back of derby defeat to Warrington – Joe Mellor and Corey Thompson will be aiming to add to their tries from last week.
St Helens thrashed Castleford 40-16 in the previous round, with the club’s Player of the Year Kyle Amor adding one of the scores.
Widnes Vikings 19-man squad: Ah Van, Brown, Buchanan, Burke, Cahill, J Chapelhow, Dean, Dudson, Farrell, Hanbury, Heremaia, Houston, Leuluai, Manuokafoa, Mellor, Runciman, Thompson, White, Whitley
St Helens 19-man squad: Lomax, Turner, Swift, Walsh, Walmsley, Roby, Amor, Vea, Wilkin, McCarthy-Scarsbrook, Richards, Thompson, Peyroux, Fages, Greenwood, Owens, McDonnell, Fleming, Knowles
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