| Cronulla Sharks — Penrith Panthers | 2018-09-14 00:00:00September 14, 2018 | Cronulla Sharks  | 21 - 20 |  Penrith Panthers | 00:00:0012:00 am | N/A |
| Penrith Panthers — New Zealand Warriors | 2018-09-08 17:30:00September 8, 2018 | Penrith Panthers | 27 - 12 |  New Zealand Warriors | 17:30:005:30 pm | N/A |
| Melbourne Storm vs Penrith Panthers | 2018-08-31 19:50:00August 31, 2018 | Melbourne Storm  | 16 - 22 | Penrith Panthers | 19:50:007:50 pm | N/A |
| Penrith Panthers vs Newcastle Knights | 2018-08-18 15:00:00August 18, 2018 | Penrith Panthers | 12 - 20 |  Newcastle Knights | 15:00:003:00 pm | N/A |
| Gold Coast Titans vs Penrith Panthers | 2018-08-11 15:00:00August 11, 2018 | Gold Coast Titans  | 16 - 17 | Penrith Panthers | 15:00:003:00 pm | N/A |
| Penrith Panthers vs Canberra Raiders | 2018-08-05 16:10:00August 5, 2018 | Penrith Panthers | 40 - 31 |  Canberra Raiders | 16:10:004:10 pm | N/A |
| Manly Sea Eagles vs Penrith Panthers | 2018-07-28 15:00:00July 28, 2018 | Manly Sea Eagles  | 24 - 28 | Penrith Panthers | 15:00:003:00 pm | N/A |
| Brisbane Broncos vs Penrith Panthers | 2018-07-20 19:50:00July 20, 2018 | Brisbane Broncos  | 50 - 18 | Penrith Panthers | 19:50:007:50 pm | N/A |
| Penrith Panthers vs Cronulla Sharks | 2018-07-13 18:00:00July 13, 2018 | Penrith Panthers | 12 - 24 | Cronulla Sharks | 18:00:006:00 pm | N/A |
| Penrith Panthers vs New Zealand Warriors | 2018-07-06 19:50:00July 6, 2018 | Penrith Panthers | 36 - 4 | New Zealand Warriors | 19:50:007:50 pm | N/A |
| Penrith Panthers vs Manly Sea Eagles | 2018-06-30 15:00:00June 30, 2018 | Penrith Panthers | 10 - 18 | Manly Sea Eagles | 15:00:003:00 pm | N/A |
| Sydney Roosters vs Penrith Panthers | 2018-06-15 19:50:00June 15, 2018 | Sydney Roosters  | 32 - 6 | Penrith Panthers | 19:50:007:50 pm | N/A |
| Canberra Raiders vs Penrith Panthers | 2018-06-08 18:00:00June 8, 2018 | Canberra Raiders | 22 - 23 | Penrith Panthers | 18:00:006:00 pm | N/A |
| Penrith Panthers vs St George-Illawarra Dragons | 2018-05-26 19:30:00May 26, 2018 | Penrith Panthers | 28 - 2 |  St George-Illawarra Dragons | 19:30:007:30 pm | N/A |
| Penrith Panthers vs Wests Tigers | 2018-05-17 19:50:00May 17, 2018 | Penrith Panthers | 16 - 2 |  Wests Tigers | 19:50:007:50 pm | N/A |
| Newcastle Knights vs Penrith Panthers | 2018-05-11 18:00:00May 11, 2018 | Newcastle Knights | 18 - 29 | Penrith Panthers | 18:00:006:00 pm | N/A |
| Penrith Panthers vs North Queensland Cowboys | 2018-05-04 19:50:00May 4, 2018 | Penrith Panthers | 20 - 26 |  North Queensland Cowboys | 19:50:007:50 pm | N/A |
